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The surgeon said the operation "went exceedingly well" and that Johnson would likely remain under observation for a few more days.
"All of our findings point to the gallbladder as the primary problem, but it is still possible that he is having some lingering effects from the antibiotic drug reaction," said Dr. Donald J. Wingert of Avera McKennan Hospital and University Health Center.
Johnson spokesperson Julianne Fisher told Sioux Falls' Argus Leader that she wasn't sure whether the senator suffered from gall stones, a common reason for gall bladder removal.
Johnson's health made headlines in 2006 when he was rushed to a hospital after suffering a brain hemorrhage while holding a conference call with reporters. He spent months recovering.
The incident left him with mobility limitations and slurred speech, according to the Argus Leader. Johnson, who was first elected to the Senate in 1996, won a third term two years ago.
He was first elected to Congress in 1986.
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